Endocrinology of the Menstrual Cycle

Hypothalamic-Pituitary-Ovary Axis

In the presence of a GnRH pulse, the pituitary and ovarian hormones exert mutual control over the circulating levels of one another. The complex interactions between pituitary and ovarian hormones involve forward control, positive feedback, and negative feedback mechanisms, and serve to sustain a self-perpetuating monthly endocrine cycle. The diagram below outlines the causal relationships between the relative amounts of key hormones of the menstrual cycle. Day one of the menstrual cycle begins with menstruation, which occurs at the beginning of the follicular phase. The menstrual cycle continues to ovulation, which is followed by the luteal phase.

Click on any hormone in a rectangle in the diagram below to learn more about its specific immediate effects on the circulating levels of other hormones.

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